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Search Results for " Parkinson's disease "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T3464	PHCCC	(-) PHCCC	GluR
	PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.		GluR
T1880	P7C3		Others
	The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be...		Others
T2216	Entacapone	OR-611	Transferase
	Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).		Transferase
T7729	PF-06454589		LRRK2
	PF-06454589 is a potent inhibitor of LRRK2.		LRRK2
T1770	GNE-9605		LRRK2
	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).		LRRK2
T4473	Ibiglustat	Venglustat,SAR402671,GZ402671	Transferase
	Ibiglustat (GZ402671) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthe...		Transferase
T22026	AGK7		Others , Sirtuin
	AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).		Others , Sirtuin
T8737	GR 125743		5-HT Receptor
	GR 125743 is a novel antagonist of 5-HT1B/1D receptor.		5-HT Receptor
T6726	VU0361737	ML-128,VU 0361737	GluR
	VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity...		GluR
T5139	CZC-25146 hydrochloride		LRRK2
	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.		LRRK2
T1476	Pramipexole	SND 919	Dopamine Receptor
	Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not...		Dopamine Receptor
T3053	CZC-25146	CHEMBL2397014	LRRK2
	CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.		LRRK2
T9235	GW604714X	2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-	Mitochondrial Metabolism
	GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate		Mitochondrial Metabolism
T2148	Carbidopa monohydrate	Carbidopa Hydrate,S(-)-Carbidopa	Decarboxylase , Aryl Hydrocarbon Receptor
	Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.		Decarboxylase , Aryl Hydrocarbon Receptor
T4979	Procyclidine hydrochloride	(±)-Procyclidine hydrochlorid	NMDAR , iGluR
	Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties.		NMDAR , iGluR
T3217	PF-CBP1 hydrochloride	PF-CBP1 HCl	Epigenetic Reader Domain , Histone Acetyltransferase
	PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.		Epigenetic Reader Domain , Histone Acetyltransferase
T2226	Pergolide mesylate	Pergolide mesylate salt,LY127809,Pergolide methanesulfonate	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	Pergolide mesylate salt(LY127809) is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T0229	Rivastigmine	SDZ-ENA 713,S-Rivastigmine,Exelon	AChE
	Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.		AChE
T2592	Ropinirole hydrochloride	SKF 101468 hydrochloride,SKF-101468A,Ropinirole HCl	Dopamine Receptor
	Ropinirole hydrochloride (SKF-101468A) is a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole hydrochloride (SKF-101468A) is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with anti...		Dopamine Receptor
T1336	Benztropine mesylate	Benzotropine mesylate,Benzatropine mesylate,Benztropine methanesulfonate	Dopamine Receptor , AChR , Histamine Receptor
	Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.		Dopamine Receptor , AChR , Histamine Receptor
T1628	Rivastigmine tartrate	SDZ-ENA 713,ENA 713	AChR , AChE
	Rivastigmine tartrate (SDZ-ENA 713) is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON...		AChR , AChE
T6951	Pramipexole dihydrochloride hydrate	Pramipexole 2HCl Monohydrate,Mirapex	Dopamine Receptor
	Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su...		Dopamine Receptor
T21667	FAUC-365	FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide,FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide	Dopamine Receptor
	FAUC-365 is a D3 dopamine receptor agonist.		Dopamine Receptor
T1406	Amantadine hydrochloride	1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor , Influenza Virus
	Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.		Dopamine Receptor , Influenza Virus
T0218	Biperiden	Bipariden,Akineton,KL 373,Biperidine	AChR
	Biperiden (Bipariden) is a muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. ...		AChR
T24064	Fipamezole	JP-1730,BVF-025,JP 1730,JP1730	Adrenergic Receptor
	Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease.		Adrenergic Receptor
T22595	B2	Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	Others , Sirtuin
	B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease		Others , Sirtuin
TQ0289	LY450108		iGluR
	LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.		iGluR
T71707L	Romergoline 2HCl	Romergoline 2HCl(107052-56-2 Free base),FCE 23884 2HCl	Dopamine Receptor
	Romergoline 2HCl is a D1 agonist and D2 antagonist used in the study of Parkinson's disease.		Dopamine Receptor
T31773	Fenlean	FLZ
	Fenlean (FLZ) is currently conducting a phase I trial in the Institute of pharmacy, Chinese Academy of medical sciences as a potential treatment for Parkinson's disease.
T13248	UK-240455		NMDAR , iGluR
	UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parkinson's disease models, and is a potential candidate compoun...		NMDAR , iGluR
T62304	Minzasolmin	(R)-NPT200-11,UCB0599,DLX-313	Others
	Minzasolmin(DLX-313) is an alpha-synuclein misfolding inhibitor for the study of Parkinson's disease.		Others
T73397	ENT-C225		Trk receptor
	ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.		Trk receptor
T19922	L-m-Tyrosine	L(-)mTyrosine,L (-) m Tyrosine,LmTyrosine,3-Hydroxy-L-Phenylalanine,L-(-)-m-Tyrosine	Others
	L-m-Tyrosine (3-Hydroxy-L-Phenylalanine) is a non-natural amino acid. L-(-)-m-Tyrosine displays the potential in treating Parkinson's disease, arthritis, and Alzheimer's disease.		Others
T28367L1	BDBM50597431		NMDAR
	BDBM50597431 is an NMDA receptor modulator that may have can be used to study Alzheimer's disease and Parkinson's syndrome.		NMDAR
T34616	Seridopidine	ACR-343,ACR 343,ACR343	Dopamine Receptor
	Seridopidine (ACR343) is a modulator of dopaminergic activity that is used as an oral therapy for schizophrenia, Parkinson's disease, and Tourette's syndrome.		Dopamine Receptor
T31592	E6801	E 6801,E-6801	5-HT Receptor
	E6801 is a novel selective 5-HT6 receptor agonist with a wide range of biological activities.E6801 can be used in the study of dementia, Parkinson's disease, depression, obesity epilepsy, anxiety, and many other diseases...		5-HT Receptor
T4081	MPTP hydrochloride	MPTP-hydrochloride	Apoptosis , Dopamine Receptor
	MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in th...		Apoptosis , Dopamine Receptor
T71934	Atibeprone		MAO
	Atibeprone is a MAO-B inhibitor with antidepressant activity for the study of Parkinson's disease.		MAO
T77333L	(Iso)-BMT-124110 Formate	(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）	AAK1 (AP2 associated kinase 1)
	(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease.		AAK1 (AP2 associated kinase 1)
T6962	Rasagiline Mesylate	TVP1012,AGN1135,Azilect	Apoptosis , MAO , Autophagy , Monoamine Oxidase
	Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.		Apoptosis , MAO , Autophagy , Monoamine Oxidase
T3278	Piribedil	EU-4200,Trivastan,ET-495,Trivastal	Dopamine Receptor , Histone Methyltransferase , Adrenergic Receptor
	Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
TQ0220	KR-33493	KR-33494,KM-819	Fas/FasL
			Fas/FasL
T40018	4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		Others
	4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione has potential as an anticancer, prodrug for the treatment of Parkinson's disease, and as an anti-inflammatory agent.		Others
T9970	MGluR3 modulator-1	1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile	GluR
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.		GluR
T67942	Antimicrobial agent-21		MAPK
	Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of cataracts, ulcerative colitis, meningitis and Kawasaki's dis...		MAPK
T6946	Pimavanserin tartrate	ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin	5-HT Receptor
	Pimavanserin tartrate (Nuplazid) is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease.		5-HT Receptor
T62568	IXA6		IRE1
	IXA6 is a novel IRE1/XBP1s agonist with potential vasoprotective activity that activates IRE1-XBP1s signaling and XBP1s transcriptional response, which can be used to study neurodegenerative diseases such as Parkinson's ...		IRE1
T76861	Cinpanemab	BIIB054	Others
	Cinpanemab (BIIB054) is a novel human monoclonal antibody with affinity for alpha-synuclein residues 1-10. Cinpanemab can be used to study Parkinson's disease and related diseases.		Others
T26537	AC-186	AC186,AC 186	Estrogen/progestogen Receptor
	AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study o...		Estrogen/progestogen Receptor

Compounds

Synonym: Venglustat,SAR402671,GZ402671

Target: Others, Sirtuin

GR 125743

T8737

Synonym:

Target: 5-HT Receptor

VU0361737

T6726

Synonym: ML-128,VU 0361737

Target: GluR

CZC-25146 hydrochloride

Target: Dopamine Receptor

CZC-25146

T3053

Synonym: CHEMBL2397014

Target: LRRK2

GW604714X

T9235

Synonym: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Target: Mitochondrial Metabolism

Carbidopa monohydrate

T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Procyclidine hydrochloride

T4979

Synonym: (±)-Procyclidine hydrochlorid

Target: NMDAR, iGluR

PF-CBP1 hydrochloride

T3217

Synonym: PF-CBP1 HCl

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Pergolide mesylate

T2226

Synonym: Pergolide mesylate salt,LY127809,Pergolide methanesulfonate

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Rivastigmine

T0229

Synonym: SDZ-ENA 713,S-Rivastigmine,Exelon

Target: AChE

Ropinirole hydrochloride

T2592

Synonym: SKF 101468 hydrochloride,SKF-101468A,Ropinirole HCl

Target: Dopamine Receptor

Benztropine mesylate

T1336

Synonym: Benzotropine mesylate,Benzatropine mesylate,Benztropine methanesulfonate

Target: Dopamine Receptor, AChR, Histamine Receptor

Rivastigmine tartrate

T1628

Synonym: SDZ-ENA 713,ENA 713

Target: AChR, AChE

Pramipexole dihydrochloride hydrate

T6951

Synonym: Pramipexole 2HCl Monohydrate,Mirapex

Target: Dopamine Receptor

FAUC-365

T21667

Synonym: FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide,FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide

Target: Dopamine Receptor

Amantadine hydrochloride

T1406

Synonym: 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

Biperiden

T0218

Synonym: Bipariden,Akineton,KL 373,Biperidine

Target: AChR

Fipamezole

T24064

Synonym: JP-1730,BVF-025,JP 1730,JP1730

Target: Adrenergic Receptor

T22595

Synonym: Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

Target: Others, Sirtuin

Synonym: Romergoline 2HCl(107052-56-2 Free base),FCE 23884 2HCl

Target: Dopamine Receptor

Synonym: (R)-NPT200-11,UCB0599,DLX-313

Synonym: L(-)mTyrosine,L (-) m Tyrosine,LmTyrosine,3-Hydroxy-L-Phenylalanine,L-(-)-m-Tyrosine

Synonym: ACR-343,ACR 343,ACR343

Target: Dopamine Receptor

E6801

T31592

Synonym: E 6801,E-6801

Target: 5-HT Receptor

MPTP hydrochloride

T4081

Synonym: MPTP-hydrochloride

Target: Apoptosis, Dopamine Receptor

(Iso)-BMT-124110 Formate

T77333L

Synonym: (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）

Target: AAK1 (AP2 associated kinase 1)

Rasagiline Mesylate

T6962

Synonym: TVP1012,AGN1135,Azilect

Target: Apoptosis, MAO, Autophagy, Monoamine Oxidase

Piribedil

T3278

Synonym: EU-4200,Trivastan,ET-495,Trivastal

Target: Dopamine Receptor, Histone Methyltransferase, Adrenergic Receptor

KR-33493

TQ0220

Synonym: KR-33494,KM-819

Target: Fas/FasL

4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Synonym: 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Target: GluR

Antimicrobial agent-21

T67942

Synonym:

Target: MAPK

Pimavanserin tartrate

T6946

Synonym: ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin

Target: 5-HT Receptor

Synonym: AC186,AC 186

Target: Estrogen/progestogen Receptor

カタログ番号	製品名	別名	ターゲット
T6795	Carbidopa	(S)-(-)-Carbidopa,Lodosyn	Decarboxylase , Aryl Hydrocarbon Receptor
	Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.		Decarboxylase , Aryl Hydrocarbon Receptor
T0437	Inosine	INO 495,NSC 20262	ROS , Endogenous Metabolite , Adenosine Receptor
	Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.		ROS , Endogenous Metabolite , Adenosine Receptor
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T0848	L-DOPA	Levodopa,3,4-Dihydroxyphenylalanine	Dopamine Receptor , Endogenous Metabolite
	L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brai...		Dopamine Receptor , Endogenous Metabolite
T5S0754	Isoquercetin	3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside	NF-κB , Wnt/beta-catenin , NO Synthase
	1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ...		NF-κB , Wnt/beta-catenin , NO Synthase
T4S2126	Ginkgetin		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 ...		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T4954L	Smilagenin	PYM50028,Cogane,AI3-44895,PYM 50028
	Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease.
T15255	Etilevodopa	Levodopa ethyl ester,L-DOPA ethyl ester	Others
	Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levo...		Others

天然物製品

Carbidopa

T6795

Synonym: (S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Inosine

T0437

Synonym: INO 495,NSC 20262

Target: ROS, Endogenous Metabolite, Adenosine Receptor

Amantadine

T7060

Synonym: 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine

Target: Others

L-DOPA

T0848

Synonym: Levodopa,3,4-Dihydroxyphenylalanine

Target: Dopamine Receptor, Endogenous Metabolite

Isoquercetin

T5S0754

Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside

Target: NF-κB, Wnt/beta-catenin, NO Synthase

Ginkgetin

T4S2126

Synonym:

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

Smilagenin

T4954L

Synonym: PYM50028,Cogane,AI3-44895,PYM 50028

Target:

Etilevodopa

T15255

Synonym: Levodopa ethyl ester,L-DOPA ethyl ester

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02512	Alpha-Synuclein Protein, Human, Recombinant	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I...
TMPY-01355	Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth an...
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293)	Human	HEK293
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-05446	CD200 Protein, Human, Recombinant (hFc)	Human	HEK293
	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-04356	GSK3B Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ...
TMPK-01063	LRP-10 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	LDL receptor-related protein (LRP) 10 was recently identified as a Parkinson's disease gene through genome-wide linkage and sequencing analysis, but its role in Parkinson's disease in various populations is still unclear...
TMPY-06318	Alpha-Synuclein Protein,Human,Recombinant (H50Q)	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPY-02043	PARK7/DJ-1 Protein, Human, Recombinant (His)	Human	E. coli
	Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress....
TMPY-06460	Alpha-Synuclein Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPY-00568	CDNF Protein, Human, Recombinant (His)	Human	HEK293
	Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionaril...
TMPY-00188	CDNF Protein, Human, Recombinant (hFc)	Human	HEK293
	Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionaril...
TMPY-05099	GBA/glucocerebrosidase Protein, Human, Recombinant (His)	Human	HEK293
	Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramida...
TMPY-04195	CHRNB3 Protein, Human, Recombinant (hFc)	Human	HEK293
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec...
TMPY-00554	CHRNB3 Protein, Human, Recombinant (His)	Human	HEK293
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec...
TMPY-01916	CDNF Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionaril...
TMPY-02446	GAPDH Protein, Human, Recombinant (His)	Human	E. coli
	Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate...
TMPJ-01022	SUMO3 Protein, Human, Recombinant (HEK293, His)	Human	Human Cells
	Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way...
TMPY-00506	GAPDH Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate...
TMPJ-00023	SNCA Protein, Human, Recombinant (His)	Human	E. coli
	Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist...
TMPJ-00683	SNCA Protein, Mouse, Recombinant	Mouse	E. coli
	Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist...
TMPY-02748	LRP-10 Protein, Human, Recombinant (His)	Human	HEK293
	LRP10 (low-density lipoprotein Receptor Related Protein 10) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a low-density lipoprotein receptor family protein. A simi...
TMPY-02653	LRP-10 Protein, Human, Recombinant (hFc)	Human	HEK293
	LRP10 (low-density lipoprotein Receptor Related Protein 10) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a low-density lipoprotein receptor family protein. A simi...
TMPY-03227	CISD1 Protein, Human, Recombinant (His)	Human	E. coli
	Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioe...
TMPY-03653	CTRL Protein, Human, Recombinant (His)	Human	HEK293
	CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is...
TMPY-01060	DOPA Decarboxylase/DDC Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the...
TMPY-02472	DOPA Decarboxylase/DDC Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the...
TMPJ-00684	SNCA Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's ...
TMPY-02759	Kallikrein 6/KLK6 Protein, Human, Recombinant (His)	Human	HEK293
	KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence...
TMPY-03595	CD200 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-01071	CD200 Protein, Human, Recombinant (His)	Human	HEK293
	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-06791	CD200 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-03380	CD200 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-05638	CD200 Protein, Human, Recombinant (hFc & Avi)	Human	HEK293
	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-04535	GDNF Protein, Canine, Recombinant (hFc)	Canine	HEK293
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-01160	CD200 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-06970	GDNF Protein, Human, Recombinant	Human	E. coli
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-02911	GDNF Protein, Rat, Recombinant (His)	Rat	Baculovirus-Insect Cells
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-04439	GSK3B Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ...
TMPY-02587	Tyrosine Hydroxylase Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw...
TMPY-02401	Tyrosine Hydroxylase Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathw...
TMPY-02175	UCHL1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis b...
TMPY-01547	UCHL1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis b...
TMPY-02331	UCHL1 Protein, Rat, Recombinant (His)	Rat	E. coli
	Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis b...

Alpha-Synuclein Protein, Human, Recombinant

TMPY-02512

Species: Human

Expression System: E. coli

BDNF Protein, Human/Murine/Rat, Recombinant

TMPJ-00135

Species: Human,Mouse,Rat

Expression System: E. coli

Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)

TMPY-01355

Species: Human

Expression System: Baculovirus-Insect Cells

GDNF Protein, Human, Recombinant (HEK293)

TMPY-02792

Species: Human

Expression System: HEK293

CD200 Protein, Human, Recombinant (hFc)

TMPY-05446

Species: Human

Expression System: HEK293

GSK3B Protein, Human, Recombinant (His)

TMPY-04356

Species: Human

Expression System: Baculovirus-Insect Cells

LRP-10 Protein, Mouse, Recombinant (His)

TMPK-01063

Species: Mouse

Expression System: HEK293

Alpha-Synuclein Protein,Human,Recombinant (H50Q)

TMPY-06318

Species: Human

Expression System: E. coli

PARK7/DJ-1 Protein, Human, Recombinant (His)

TMPY-02043

Species: Human

Expression System: E. coli

Alpha-Synuclein Protein, Mouse, Recombinant (His)

TMPY-06460

Species: Mouse

Expression System: E. coli

CDNF Protein, Human, Recombinant (His)

TMPY-00568

Species: Human

Expression System: HEK293

CDNF Protein, Human, Recombinant (hFc)

TMPY-00188

Species: Human

Expression System: HEK293

GBA/glucocerebrosidase Protein, Human, Recombinant (His)

TMPY-05099

Species: Human

Expression System: HEK293

CHRNB3 Protein, Human, Recombinant (hFc)

TMPY-04195

Species: Human

Expression System: HEK293

CHRNB3 Protein, Human, Recombinant (His)

TMPY-00554

Species: Human

Expression System: HEK293

CDNF Protein, Mouse, Recombinant (His)

TMPY-01916

Species: Mouse

Expression System: HEK293

GAPDH Protein, Human, Recombinant (His)

TMPY-02446

Species: Human

Expression System: E. coli

SUMO3 Protein, Human, Recombinant (HEK293, His)

TMPJ-01022

Species: Human

Expression System: Human Cells

GAPDH Protein, Mouse, Recombinant (His)

TMPY-00506

Species: Mouse

Expression System: E. coli

SNCA Protein, Human, Recombinant (His)

TMPJ-00023

Species: Human

Expression System: E. coli

SNCA Protein, Mouse, Recombinant

TMPJ-00683

Species: Mouse

Expression System: E. coli

LRP-10 Protein, Human, Recombinant (His)

TMPY-02748

Species: Human

Expression System: HEK293

LRP-10 Protein, Human, Recombinant (hFc)

TMPY-02653

Species: Human

Expression System: HEK293

CISD1 Protein, Human, Recombinant (His)

TMPY-03227

Species: Human

Expression System: E. coli

CTRL Protein, Human, Recombinant (His)

TMPY-03653

Species: Human

Expression System: HEK293

DOPA Decarboxylase/DDC Protein, Human, Recombinant (His)

TMPY-01060

Species: Human

Expression System: Baculovirus-Insect Cells

DOPA Decarboxylase/DDC Protein, Mouse, Recombinant (His)

TMPY-02472

Species: Mouse

Expression System: Baculovirus-Insect Cells

SNCA Protein, Mouse, Recombinant (His)

TMPJ-00684

Species: Mouse

Expression System: E. coli

Kallikrein 6/KLK6 Protein, Human, Recombinant (His)

TMPY-02759

Species: Human

Expression System: HEK293

CD200 Protein, Rhesus, Recombinant (His)

TMPY-03595

Species: Rhesus

Expression System: HEK293

CD200 Protein, Human, Recombinant (His)

TMPY-01071

Species: Human

Expression System: HEK293

CD200 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-06791

Species: Human

Expression System: HEK293

CD200 Protein, Rhesus, Recombinant (hFc)

TMPY-03380

Species: Rhesus

Expression System: HEK293

CD200 Protein, Human, Recombinant (hFc & Avi)

TMPY-05638

Species: Human

Expression System: HEK293

GDNF Protein, Canine, Recombinant (hFc)

TMPY-04535

Species: Canine

Expression System: HEK293

CD200 Protein, Mouse, Recombinant (His)

TMPY-01160

Species: Mouse

Expression System: HEK293

GDNF Protein, Human, Recombinant

TMPY-06970

Species: Human

Expression System: E. coli

GDNF Protein, Rat, Recombinant (His)

TMPY-02911

Species: Rat

Expression System: Baculovirus-Insect Cells

GSK3B Protein, Mouse, Recombinant (His)

TMPY-04439

Species: Mouse

Expression System: Baculovirus-Insect Cells

Tyrosine Hydroxylase Protein, Mouse, Recombinant (His)

TMPY-02587

Species: Mouse

Expression System: Baculovirus-Insect Cells

Tyrosine Hydroxylase Protein, Human, Recombinant (His)

TMPY-02401

Species: Human

Expression System: Baculovirus-Insect Cells

UCHL1 Protein, Mouse, Recombinant (His)

TMPY-02175

Species: Mouse

Expression System: E. coli

UCHL1 Protein, Human, Recombinant (His)

TMPY-01547

Species: Human

Expression System: E. coli

UCHL1 Protein, Rat, Recombinant (His)

TMPY-02331

Species: Rat

Expression System: E. coli

カタログ番号	製品名
L9830	Anti-Parkinson's Disease Compound Library	857 compounds
	A unique collection of 857 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS.
L2630	Neuronal Differentiation Compound Library	672 compounds

ライブラリー

Anti-Parkinson's Disease Compound Library

L9830

Compounds: 857

Neuronal Differentiation Compound Library

L2630

Compounds: 672